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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use of routinely available equipment.
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Pragmatic, a software company provides a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as casinos that are located in the land. The company provides front-end design tools, analysis tools, marketing, promotions, payment systems, security, customer service and bug reporting. The company also offers security, high-quality graphics, gaming and security.
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A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity could cause issues with the design of the trial.
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Legality
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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They are also a good way to identify the causal relationship between an intervention and its outcomes. They should, however, not, be used to replace explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a practical trial that include the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.